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Dose-dependent inhibition of growth hormone (GH)-releasing hormone-induced GH release by corticotropin-releasing hormone in prepubertal children

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After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 days or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 days

K., Khandelwal, R

If you are planning pregnancy, discontinue semaglutide at least 2 months before attempting to conceive (the medication has a 5-week half-life)