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It is also worth reiterating that Rybelsus must be taken on an empty stomach with a small amount of water (up to 120 ml), swallowed whole, and food or other medications should be avoided for at least 30 minutes afterwards to ensure proper absorption

The timeline below breaks down onset and duration by effect type, so you know what to expect and when

While specific studies on oral contraceptive absorption with GLP-1 medications are limited, some providers recommend backup contraception during the first month of treatment and for a week after dose increases if using oral birth control as your primary method