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In humans, case reports and small-scale studies have observed that weight loss in obese patients treated with GLP-1RAs coincides with amelioration of anxiety symptoms

Intestinal inflammation, dysbiosis, or increased permeability can significantly reduce DAO production and allow dietary histamine to enter circulation unchecked

Deficiency symptoms in children include developmental delay, regression, irritability, involuntary movements, and hypotonia

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Additionally, many patients experience weight regain when they stop the injections, as the drugs blunt the bodys natural weight-regulating systems rather than support them