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In the context of hemorrhoidal tissue, TB-4 enhances re-epithelialization (the reformation of the protective mucosal layer) and reduces inflammatory cytokine production via the NF-B pathway

doi: 10.1038/s41467-024-49133-z 370 WangR.LanC.BenlaghaK.CamaraN

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A study using a three-dimensional tumour sphere model combined with CRISPR-Cas9 screening reported that Nrf2 overactivation was essential for lung tumour proliferation and survival, whereas silencing of Nrf2 predisposed spherical cells to ferroptosis, which was also consistent with clinical observations [77]