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However, kidneys can be quite sensitive to additional substances we introduce into the body, especially if there is already some kidney dysfunction present

doi: 10.1093/emboj/17.19.5543 72 TaoK

Prescribing decisions are made independently by licensed healthcare professionals after evaluating individual medical history and clinical suitability

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It seems that weight loss will likely be very important for the benefits of the GLP-1 medicines in some conditions, and much less important, or not at all essential, for benefits in other disorders. According to Lane, although GLP-1 receptor agonists show promise in reducing cardiovascular risk factors, long-term cardiovascular safety trials are needed to assess cardiovascular mortality and events