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Notably, these melanomas have a metastasis spectrum similar to that observed in humans with melanoma

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Moving on PT-141 is a synthetic peptide analog of alpha-melanocyte-stimulating hormone (-MSH)

Specifically, the BA metabolites 3-oxolithocholic acid (3-oxoLCA) and iso-lithocholic acid (isoLCA) impede Th17 cell differentiation by directly binding to retinoic acid receptor-related orphan receptor gamma t (RORt), a key transcriptional promoter of Th17 cells ( Figure 2 )