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Regarding weight loss, the FDA has approved these drugs for people whose body mass index (BMI) is greater than 30 kg/m2, or they have a BMI that is greater than 27 and have a weight-related health problem, such as high blood pressure, sleep apnea, or pre-diabetes

PMID: 29756566 View source Malinda KM, et al

This defective metabolism becomes more apparent with increasing levels of fat consumption in the diet

Kroemer G

Mol Hum Reprod 8(2):124135 De Filippis L, Halikere A, McGowan H, Moore JC, Tischfield JA, Hart RP, Pang ZP (2016) Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells