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The copper peptide concentration matters significantly for under-eye use, with 0.5-1% proving optimal balance between effectiveness and minimizing irritation risk in this sensitive area, while higher concentrations (1-2%) used successfully on face may prove too irritating for periorbital application

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Mild injection-site reactions, transient hunger (mild ghrelin-receptor activation), rare water retention, rare mild flushing

Those interested in using it should weigh the potential risks of side effects against any benefits they may receive from taking the peptide

A pivotal role for fibroblast-derived growth factors in regulating hyperpigmentation has recently been suggested