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To sum up, GLP-1 receptor agonists protect neurons through several pathways including the classic cAMP/PKA/CREB pathway, the PI3K/Akt pathway, controlling inflammation, and keeping mitochondria working as shown in Figure 1

Our results revealed that DSS induction significantly reduced gut microbial diversity in mice, as evidenced by decreased Shannon and Simpson indices-a finding consistent with the characteristic reduction in microbial diversity observed in patients with inflammatory bowel disease ( Lactobacillus , Akkermansia and Odoribacter

Nontargeted identification of reactive metabolite protein adducts

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