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Beyond tirzepatide, several older injectable GLP-1 agonists remain in clinical use and can serve as alternatives depending on the clinical goal

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Taken together, available data support a central role of mitochondriacytoskeleton crosstalk in maintaining mitochondrial distribution, morphology, and quality control in PACs and in determining whether cells adapt to injury or progress toward death in AP ( 3.3 Mitochondria and the plasma membrane At the cell periphery, these intracellular mechanisms converge on the plasma membrane, where calcium entry both drives physiological secretion and, when excessive, perpetuates mitochondrial injury