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Transcriptome analysis of pathway enrichment (Supplemental Figure 6A) and gene set enrichment analysis (GSEA) Supplemental Figure 6B) indicated that the hallmark pathway of glutamine family amino acid metabolic process was among the top-ranking upregulated gene sets in A2ARi-treated cells

Specific pathways activated include heat shock proteins and NRF2 detoxification pathways

Repeatedly using the same spot can cause hardening of the tissue (lipodystrophy), which can affect absorption

Vitamin D plays a very prominent role in immune responses and low vitamin D status is often described in the context of autoimmune and inflammatory diseases

The study found no significant differences between active treatments and placebo in either biochemical or behavioral measures, although all groups showed mild improvements over time, likely reflecting nonspecific effects