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Other side effects included decreased appetite and fatigue

Suvarna R et al

While it may feel counterintuitive to go back to a lower dose after building tolerance to another GLP-1 medication, this approach helps prevent gastrointestinal intolerance and supports better long-term adherence

N Engl J Med (2019) 380(24):2295306

That number is not just large in absolute terms, it is the largest weight-loss signal ever reported in a randomized Phase 3 trial of a GLP-1-class compound, and it arrived with additional secondary findings that reframe what "GLP-1 therapy" could eventually mean: a 75.8% reduction in osteoarthritis pain, a roughly 20% drop in LDL cholesterol, and a 72% reversal rate of prediabetes to normoglycemia in the affected subpopulation