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FOXO4-DRI effectively counteracted doxorubicin-induced cell senescence and additionally mitigated doxorubicin-induced loss of body mass and elevated levels of aspartate aminotransferase (AST), contributing to the reduction of the hepatotoxicity of the chemotherapy agent [127]

This is even more important if you have B12 deficiency and need significantly higher doses

Yes, and it may enhance your HRT outcomes

Other sources of superoxide can be enzymatic reactions that transfer electrons to the ETC such as mitochondrial glycerol 3-phosphate dehydrogenase (mGPDH), and the last step of -oxidation, electron-trasferring flavoprotein ubiquinone oxidoreductase (ETFQOR) or dehydrogenases such as pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxoacid dehydrogenase (BCKDH)

Always consult a licensed healthcare provider before starting any new supplement or making significant changes to your diet or lifestyle