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SGLT2 inhibitors stimulate hepatic glucose production and also increase glucagon secretion, which promotes endogenous glucose production and restricts their glucose-lowering capacity [34]

This enhanced circulation may support oxygen and nutrient delivery to muscles and tissues, making it popular among athletes and individuals focused on heart health

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The SURMOUNT-1 Trial (Mounjaro/Zepbound) In the landmark SURMOUNT-1 trial, participants taking the highest dose of tirzepatide (15 mg) lost an average of 22.5% of their body weight over 72 weeks

The two are studied through different primary mechanisms, and the distinction matters for anyone comparing them: Because the two proposed pathways are largely complementary rather than overlapping, some laboratories investigate both peptides within the same tissue-repair research protocols