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Inhaled (nebulized or aerosolized) reduced GSH to augment the deficient GSH levels of the lower respiratory tract has been used effectively in numerous pulmonary diseases and respiratory conditions like HIV seropositive individuals, cystic fibrosis and idiopathic pulmonary fibrosis, among others (131133)

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As mentioned before, these other three ingredients were added to support the role of glutathione as a skin-lightening agent to yield a synergistic effect as a depigmenting agent, in absorption, and in capsule formulations

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This suggests that NP4 could effectively promote the polarization of M2-type macrophages towards M1-type macrophages, thereby alleviating immune suppression