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cDNA was synthesized using the Transcription First-Strand cDNA Synthesis Kit (Roche Diagnostics, Basel, Switzerland

Therefore, SLC7A11 prevents cells from undergoing ferroptosis by importing cystine and promoting GSH synthesis

Mechanistically, CX-5461 modulates CD36-ACSL4-mediated glycerophospholipid metabolism in B cells, triggers ferroptosis via the p53-SLC7A11- Arachidonate 12-Lipoxygenase (ALOX12) pathway and lowers IgG and anti-dsDNA antibody levels, thus attenuating lupus pathogenesis

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Read More Draft for Comments || Enhanced Regulatory Support and Priority Processing Lanes for Licensing and Registration Applications Involving Locally Produced Pharmaceutical Products 17 June 2026 All comments can be sent at [email protected]