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The tissue homogenates were centrifuged for 12000 x g for 15 min and collected and diluted to 1 mg tissue protein per ml (1 mg/ml) in homogenization buffer (PBS, pH 7.4, containing a protease inhibitor cocktail) as the stock solution

A receptor agonist is a medication that mimics this hormone to produce a specific response in the body

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In a 24-week open-label Phase I/II clinical trial (Clinicaltrials.gov Identifier: NCT00779194) in patients with active SLE, sirolimus treatment increased the proportion of circulating Foxp3+ Tregs, suppressed IL-17 and IL-4 secretion, and facilitated glucocorticoid tapering (mean prednisolone dose reduced from 23.7 mg to 7.2 mg daily) (236)

or 525 mg ALCAR & 225 mg ALA in 1 capsule