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These studies presented a more mixed picture, but over all they showed some benefit for most normal healthy subjectsespecially for people who had inherently poorer cognitive control

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To this day, several clinical trials are ongoing in a large panel of age-related diseases, but their validation remains uncertain (Table 1)

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Orforglipron In phase II, randomized, double-blind study, adults with overweight or obesity and without T2DM who took oral orforglipron (12, 24, 36, or 45 mg) daily for 36 weeks experienced a weight reduction of 9.414.7% [105]