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The lack of evidence is not surprising given the many definitions of the disorder employed and the focus of most trials on National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) diagnostic criteria (note that the NIDDK diagnostic criteria are not appropriate for use outside of clinical trials)

Fukuda H, Takekuma M, Hirashima Y Internal medicine (Tokyo, Japan) 2020

Strikingly, we find that the disordered FOXO4-DRI binds to the disordered p53 TAD2 and forms a transiently folded complex

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10.1096/fj.04-1581fje [DOI] [PubMed] [Google Scholar] Li Y., Chigurupati S., Holloway H