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Furthermore, neuroinflammation driven by systemic oxidative stress disrupts the delicate balance of autonomic signaling in the brain, leaving patients stuck in a perpetual, exhausting 'fight or flight' state

The research framing discusses defined multi-week blocks commonly in the range of roughly 812 weeks followed by an off period before repeating, with the aim of limiting receptor down-regulation

other compounds may ultimately prove safe and useful for patient care, while others are just biologically implausible

This study established the core evidence that drives current research interest and it is important to note that this is primarily a preclinical (mouse) evidence base

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie , 57 (3-4), 145155