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Independent researchers typically administer a daily 5-amino-1MQ dose of 50-150mg of 5-amino-1MQ to human subjects

AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

The peptide molecules are clustering at a submicroscopic level, reducing potency without any visible change

That is a very different statement from they do nothing. It means: The mechanistic rationale is real