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Under oxidative stress from surgery and anesthesia, increased mtROS production and mtDNA release from the open mPTP into the cytoplasm activate the NLRP3 inflammasome, exacerbating neuroinflammation and neuronal apoptosis, which ultimately results in POCD [19, 194]

B12 supplementation decisions should be individualized based on baseline risk factors, clinical presentation, and laboratory findings rather than routine supplementation for all Zepbound users

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Your doctor will choose the best cholesterol-lowering drug for you based on your cholesterol numbers, medical history, side effects, personal preferences, and insurance coverage