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First, SELECT was designed as a CV outcomes trial and not a weight-loss trial, and weight loss was only a supportive secondary endpoint in the trial design

Both dietary approaches, when integrated with semaglutide therapy, have the potential to preserve lean body mass, reduce gastrointestinal adverse events, and enhance adherence through improved satiety and tolerability

How it works: Reduces glucose production in the liver Improves insulin sensitivity Important counseling points: Take with food to avoid gastric upset Avoid in severe kidney disease A simple drug with powerful long-term benefits

Glucose is a breakdown product of most foods we eat, even those that aren't 'sugary,' serving as your body's primary energy source

H., Cohen, R