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Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

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Collectively, these findings demonstrate sustained Exe4 expression and secretion by the liver following a single in vivo genome editing at the mouse Alb locus using LNP-mediated HITI, with no discernible side effects

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More importantly, the fusion image is displayed on a high-definition screen by integrating the fluorescent signal from the fluorescent dyes with standard unaided vision using white light imaging, thanks to advanced imaging system software