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440 These medications are administered orally or topically, in the form of pills, rectal suppositories, or enema fluids

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It has a very short half-life, approximately 12 minutes, due to rapid degradation by dipeptidyl peptidase-4 (DPP-4)

A one-size-fits-all approach leaves gaps

However, this research is in early stages and has not translated into specific clinical recommendations