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Although the OXPHOS pathway is more energy efficient, since it generates 36 moles of ATP, cancer cells rely on glycolysis, which produces less ATP faster: 2 molecules of ATP are produced from 1 molecule of glucose
Under the influence of thiolase (acetyl-CoA acetyltransferase 1, ACAT1), CoA-SH is detached from one molecule of acetyl-CoA, and acetoacetyl-CoA (AcAc-CoA) is formed
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