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Mozaffarian, D., Agarwal, M., Aggarwal, M., Alexander, L., Apovian, C

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a 10.6% weight reduction for those who used a previous medication ( P = .01)

These medications, which work by regulating appetite hormones, have demonstrated clinically significant weight reduction in peer-reviewed studies with response rates varying considerably between individuals

The JAMA study also didnt research the effects of other GLP-1 medications, including tirzepatide (brand names Mounjaro or Zepbound), which is a similar medication to semaglutide that kicked off during the Ozempic and Wegovy wave, but it works a little differently