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We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs
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dermis) to ensure the formulation strategy aligns with regulatory standards and efficacy goals
doi: 10.1073/pnas.82.14.4668 66
(2025), GPS has been shown to significantly enhance the migration and proliferation of fibroblasts, which are essential for collagen synthesis and tissue repair
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