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If considering a dose reduction for maintenance: Wait until weight has stabilized for at least 4 weeks at your current dose Reduce by one dose step (e.g., 12mg to 8mg), do not jump multiple steps Monitor weight closely for 8 weeks after the reduction If weight begins to increase, return to the previous maintenance dose The phase 3 trials specifically tested 4mg as a maintenance dose, suggesting Lilly sees viability in lower maintenance doses What happens if you stop Weight regain after discontinuing GLP-1 agonists is well documented with semaglutide and tirzepatide

What drug accumulation actually does to your body Every medication has a therapeutic window

So, the BAC limit will be much higher

Obesity rates in most regions are on the rise particularly in China and India, where many are edging away from traditional Asian diets to more calorific western-style food