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Since GSH depletion causes exacerbation of ROS production, inflammation, apoptosis and autophagy, the reversion or prevention was thought to be blocked by flavonoids, molecules derived from natural sources with antioxidant, anti-inflammatory and antiapoptotic properties

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1 These include imipramine (Tofranil), midodrine (ProAmatine), chlorpheniramine (Chlor-Trimeton), brompheniramine (Veltane), ephedrine (Akovaz), pseudoephedrine (Sudafed), and phenylephrine (Vazculep)

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Statements Author contributions CA, SQ, and SF gave the idea and drafted the manuscript