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Exposure to glutamate leads to a decrease in GSH levels and an accumulation of intracellular peroxides, resulting in oxidative stress and cell death ( As talked about previously, tumor-associated immunotherapy studies have shown that CD8 + T cells enhance ferroptosis-specific lipid peroxidation in tumor cells

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Oxygen uptake by isolated mitochondrial fractions or brain homogenates was measured polarographically using an open Clark platinum microelectrode