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From a pathological perspective, the disease is characterized by the progressive degeneration of both upper motor neurons (UMN) in the cerebral cortex and lower motor neurons (LMN) in the brain stem and spinal cord

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Because water molecules are smaller than nearly all contrast agents, its movement across the BBB is sensitive to minute changes in permeability

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Liraglutide is a prominent GLP-1RA that can attain total body weight losses and lean mass preservation