Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease
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The trial randomised 380 subjects on stable treatment with levodopa without motor complications to double-blind adjunct therapy with either 50 mg of opicapone or placebo for 24 weeks and offered transition into a 52-week extension on open-label treatment with 50 mg of opicapone for all participants [130]
