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doi: 10.3748/wjg.v29.i27.4289

2) The study performed by Li et al employed a multi-pronged experimental design, integrating human tissue analysis, in vitro cell culture, and in vivo animal models to comprehensively investigate the role of FOXO4 in age-related male fertility and the therapeutic potential of FOXO4-DRI

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These enzymes not only maintain basal metabolic flux through their catalytic activity but also participate in epigenetic regulation, transcription factor activation, redox homeostasis, and the modulation of cell death pathways, thereby acting as upstream drivers of mitochondrial metabolic reprogramming [95]

Yes, taking them together is actually highly recommended