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Prior to the behavioural procedures involving auditory startle responses (ASRs), rats were handled and acclimated (5 min) to the startle boxes and background noise (65 dB white noise)

Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1

Such models might help identify promising design motifs and module assemblies for defined TME phenotypes [109]

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