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Recent research demonstrated that the distinct insulinotropic potential of incretins in diabetes is highlighted by a Gs/Gq signaling shift in pancreatic -cells chronically exposed to high glucose 41

Freezing a reconstituted peptide causes irreversible structural damage through ice crystal formation

Future directions First, define exposureresponse with quantitative pharmacokinetics and, where possible, receptor-occupancy or target-engagement biomarkers to guide dose selection across tissues

Acknowledgements LQL held a Career Award for Medical Scientists from the Burroughs Wellcome Fund and is the Thomas L