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A likely explanation is that the BAs bound to a sequestrant into the intestinal lumen can't be absorbed and hence travel more distally in the GI tract where the complexes are still capable to activate the TGR5 expressing colonic L-cells

68,653 patients (GLP1-ra = 34,301, placebo = 34,352) from 10 trials were included

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The FDA approval is only for people with obesity, but it could help those with sleep apnea get Medicare coverage, which doesnt cover drugs just for weight loss, according to a report

It is also an issue affecting patients who had started losing weight but then are not able to continue taking the medication and start to gain weight again, she says