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Deeper, more restorative sleep Improved sleep onset Reduced cortisol and stress No next-day grogginess May help with pain perception Dosage1mg/mL, 5mL vial AdministrationSubcutaneous injection, evening About What is DSIP

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Starting dose Zepbound is started at a lower dose of 2.5 mg once weekly for the first 4 weeks to prevent the risk of gastrointestinal side effects such as nausea and vomiting

Screening for DEGs in microarray data The R software package, limma (v3.52.4) 18 , was used to conduct differential gene analysis on two PD microarray datasets (GSE49036, GSE20164)