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Once reconstituted, refrigeration is mandatory and use within 4 weeks is advisable

Zheng, S., Rao, J., Zhang, Z., Xu, J

Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial

In the COMBINE 3 trial in individuals with T2D inadequately controlled on daily basal insulin, IcoSema provided non-inferior reduction in HbA 1c from baseline to week 52 and superior body weight change and rate of combined clinically significant or severe hypoglycemia compared with basal-bolus insulin treatment that included once-daily insulin glargine U100 and insulin aspart given two to four times per day with main meals [15]

The latter is effective in avoiding repeated thawing