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Concomitant deficiencies (iron, folate), chronic illness, or drug interactions may blunt clinical response and warrant further evaluation

Raghuraman provides a detailed description of using REES for linking solvent relaxation dynamic and protein conformation and emphasizes that this technique can be used as a sensitive tool to monitor the structural plasticity of IDPs and distinguish subtle but important structural alterations in these proteins (Jain et al., 2013

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