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Physical therapy Physical therapy is the gold standard of conservative treatment and has the strongest evidence base

10.1056/NEJMoa2212948 253 VaradharajanA.DavisA

When cyp2e1 knockout mice that lack the ability to produce the CYP2E1 enzyme were challenged with acetaminophen, they were found to be considerably less sensitive to its hepatotoxic effects than wild-type animals, indicating that this CYP is the principal enzyme responsible for the metabolic conversion of the drug acetaminophen to its active hepatotoxic metabolite NAPQI (Figure 2)

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