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Based on current trial populations and how the FDA has handled semaglutide and tirzepatide approvals, expected eligibility criteria are: BMI 30 , or BMI 27 with at least one weight-related condition (type 2 diabetes, hypertension, dyslipidemia, OSA) Adults 18 and older Not pregnant or breastfeeding No history of MTC or MEN 2 Retatrutide will almost certainly launch at a high price point estimates suggest $1,200$1,500 per month at list price

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PIMSOFT software was used to select the ischemic area of ischemic limb and non-ischemic limb to measure the ROI value, and the results were expressed in the form of perfusion ratio of ischemic to non-ischemic limb