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Chronic stress reduces the appetite-suppressing effectiveness of GLP-1s, and perimenopausal estrogen decline dysregulates the HPA axis that cortisol and GLP-1 mechanisms share, raising baseline cortisol

Segundo, suprime la liberacin de glucagn, una hormona que aumenta la glucosa sangunea

For diabetes, NICE recommends continuing treatment if HbA1c reduces by at least 11 mmol/mol (1.0%) and weight decreases by at least 3% at 6 months

GLP-1s are highly effective at controlling blood sugar and slowing down gastric processes, but they are also highly effective (so to speak) at bringing on side effects like constipation, nausea, and abdominal pain that, if untreated, will impact adherence and, in turn, short and long term results

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