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The mechanisms of HIF-1a involved in acute hypobaric hypoxia include the ROS pathway, the Toll-like receptor 4 (TLR4) signaling pathway, and the autophagy pathway ( With its multi-compounds and multi-target properties, traditional Chinese medicine (TCM) has been widely used as an alternative medical treatment for various diseases (Li et al., 2020b)

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If a diet or drug causes major muscle loss, you might end up thinner but weaker, with a lower resting metabolic rate