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Zepbound Data as Reported by Lilly The manufacturers language on the weight loss indication reads thus: Zepbound is indicated in combination with a reduced-calorie diet and increased physical activity: to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition. At 72 weeks, patients taking Zepbound 15mg lost an average of 20.9% of their body weight

doi:10.1016/b978-008055232-3.60034-0

A., Smith, L

1), the study population was divided as follows: the GLP-1RA cohort consisted of patients prescribed initial GLP-1RAs between April 2013 and April 2019 who were never prescribed SGLT2 inhibitors before the initial GLP-1RAs prescription, and the SGLT2 cohort consisted of patients prescribed initial SGLT2 inhibitors between April 2013 and April 2019 who were never prescribed GLP-1RAs before the initial SGLT2 prescription

Timing matters because glutathione competes with food amino acids for intestinal transport