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The creatine/phosphocreatine (PCr) system functions as a spatial energy buffer between the cytosol and mitochondria using a unique mitochondrial creatine kinase (CK) isoform, which is found in the intermembrane space of mitochondria
In GDM, the placenta is susceptible to a hyperglycemic environment, accompanied by changes of heightened inflammation and oxidative stress, dyslipidemia, and altered hormone levels
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