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(Wilding et al., NEJM, 2021 PubMed: 33567185) STEP 2 Trial (2021) In patients with both obesity and type 2 diabetes, semaglutide 2.4 mg produced mean weight loss of 9.6% versus 3.4% with placebo at 68 weeks

Expect: Appetite changes Nausea for some Fluctuations in energy levels Dose escalation and careful titration reduce many early side effects

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This ongoing supervision is what separates a safe, effective outcome from a guesswork approach

[ Randomized controlled trial, limited recommendation ] Key question Is early intensification of pharmacologic treatment (combination therapy of different classes) more effective in improving health outcomes compared to delayed treatment intensification in people with T2DM