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Not surprising The researchers were not surprised by the results, according to co-study author Dr

Kalyani RR, Corriere M, Ferrucci L

This peptide hormone is well known for its mediative effect in regulating cellular glucose transport in the periphery and has been demonstrated to cross the BBB through insulin transporters [128] to act on insulin receptors which are widespread throughout the brain, localized on neurons, astrocytes, and microglia [129,130,131]

Semaglutide is a synthetic GLP-1 receptor agonist

The transition from 1mg to 1.7mg represents one of the larger proportional dose jumps in the semaglutide titration schedule