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Understanding both receptor expression patterns and subsequent signaling cascades illuminates how these agents exert their beneficial cardiovascular actions beyond glycemic control

The mechanism underlying the regulation of glucose homeostasis by E2 signaling is that the ER-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus can sense glucose fluctuations throughout the body and regulate glucose homeostasis [194]

Serum corticosteroid-binding globulin concentration and insulin resistance syndrome: a population study

Importantly, correlation analysis of AGEs bone content with LEF1 gene expression levels showed a negative association (r=-0.55