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Thus, HO-1 plays significant part in regulating the progression and application of DN (Fig

Besides, the transporter is also expressed in other tissues, and independent data (114116) show a less drastic difference between human colonocytes and enterocytes in its expression (Figure 2B), compared to the initial finding of a 10-fold higher expression in the colon relative to other regions of gastrointestinal tract in humans (117)

9, 10, 11 To this end, a group of 11 metabolic physicians, registered dietitian nutritionists, and psychologist from the United States and Canada with experience in providing care for patients with HT-1 initiated a consensus-based process to establish uniform recommendations for identification and treatment of affected children